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Link or Title: Hypoglycemic agents plus acarbose vs hypoglycemic agents plus Psyllium platago in the metabolic control of non-insulin-dependent diabetes mellitus
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توضیحات: Hypoglycemic agents plus acarbose vs hypoglycemic agents plus Psyllium platago in the metabolic control of non-insulin-dependent diabetes mellitus H. Arreola Mucino, G. Callejas Hernandez, O. Hernandez Aguirre and L. Ornelas Bernal Medicina Interna de Mexico 1998 Vol. 14 Issue 6 Pages 259-262 https://www.scopus.com/inward/record.uri?eid=2-s2.0-0032467014&partnerID=40&md5=ccc9ad310bdd35d2261252c8a6d64b8b Background: The non-insulin-dependent diabetes mellitus (NIDDM) is a very important cause for morbidity and mortality in humans. The therapy purpose is to reach the normoglycemia and, in this way, to avoid later complications. They have settled down several therapeutic strategies, they include diet, physical exercise and medications, as sulfonylureas, biguanides, insulin, and α-glucosidase inhibitors. Objective: To compare the efficacy of the acarbose or Psyllium plantago plus oral hypoglycemic agents in the control of the glycemia in the non-insulin dependent diabetic patients. Material and methods: A clinical open study, randomized, controlled, with parallel group was done. The inclusion criteria were: a) Noninsulin-dependent diabetes mellitus patient with a hemoglobin A(1c) (HbA(1c)) level >8% despite of use of oral hypoglycemic agents and diet; b) glycemia in fast > 140 mg/dl, and/or postprandial glycemia of 2 hours >180 mg/dl; c) creatinine clearance >30 ml/min, and d) LDL levels >150 mg/dl. Patients were randomly assigned to one of the two groups of treatment, group of oral hypoglycemic agent plus acarbose, and group of oral hypoglycemic agent plus Psyllium plantago (P). Assessment of fast and postprandial glucose, hemoglobin A(1c) (HbA(1c)), and low density lipoproteins (LDL) was done. Central tendency and dispersion of all the variables frequency and measures were calculated, and the quantitative variables were analyzed by t Student test means. The statistical significance settled down with a p

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