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Link or Title: Effects of psyllium on cholesterol and low-density lipoprotein metabolism in subjects with hypercholesterolemia
DOI: Effects of psyllium on cholesterol and low-density lipoprotein metabolism in subjects with hypercholesterolemia
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توضیحات: Effects of psyllium on cholesterol and low-density lipoprotein metabolism in subjects with hypercholesterolemia K. W. Weingand, N. A. Le, B. R. Kuzmak, W. V. Brown, B. P. Daggy, T. A. Miettinen, et al. Endocrinology and Metabolism 1997 Vol. 4 Issue 2 Pages 141-150 Accession Number: WOS:A1997XT15300009 Psyllium's hypocholesterolemic effects are well documented, but the mechanisms for these effects remain unclear. Therefore, the effect of twice-daily psyllium treatment on cholesterol metabolism in hypercholesterolemic patients was studied. Low-density lipoprotein (LDL) turnover (two-pool model using autologous I-125-labeled LDL), serum lipoprotein lipids and serum sterol levels were studied in 23 adult men and women with primary hypercholesterolemia. Volunteers were recruited to consume an American Heart Association (AHA) Step I diet for a 12-week diet lead-in phase. Eligible subjects continued on the AHA Step I diet and were randomly assigned to receive 5.1 g of either psyllium or cellulose placebo twice daily for 8 weeks. Subjects were then crossed to the other treatment for an additional 8 weeks. Psyllium treatment significantly decreased serum LDL cholesterol levels (P