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Link or Title: Effects of intake of psyllium husk on blood pressure in subjects with high-normal blood pressure -Randomized, double-blind, placebo-controlled parallel-group study
DOI: Effects of intake of psyllium husk on blood pressure in subjects with high-normal blood pressure -Randomized, double-blind, placebo-controlled parallel-group study
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توضیحات: Effects of intake of psyllium husk on blood pressure in subjects with high-normal blood pressure -Randomized, double-blind, placebo-controlled parallel-group study H. Yoshinuma, N. Inoike, S. Tanabe, S. Ebihara and F. Nakamura Japanese Pharmacology and Therapeutics 2019 Vol. 47 Issue 9 Pages 1519-1527 https://www.scopus.com/inward/record.uri?eid=2-s2.0-85074261878&partnerID=40&md5=702798fd353eebfbd0319f3e617fc915 Objectives This study aimed to investigate the effects of psyllium husk intake on blood pressure in high-normal blood pressure subjects. Methods A randomized, double-blind, placebo-controlled, parallel-group study was conducted in 72 high-normal blood pressure subjects. The subjects were randomly assigned to either the psyllium group (n=36) or the placebo-controlled group (n=36). The subjects consumed the study product before each of the three daily meals for 12 weeks. The psyllium group consumed test food containing 3.6 g of dietary fiber derived from psyllium husk at a time, and the placebo group consumed control food without dietary fiber derived from psyllium husk. The changes in the blood pressure levels of the two groups were compared. Results Seventy subjects completed the study. Systolic blood pressure (SBP) and diastolic blood pressure (DBP) of the two groups were not significantly different. However, subgroup analysis of subjects whose estimated daily salt intake during the study were above the mean of subjects revealed that the change from baseline to Week 12 in SBP was significantly greater in psyllium group (P

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